| 摘要 |
1385943 Cephalosporin compounds TAKEDA YAKUHIN KOGYO KK 4 April 1972 [2 April 1971] 15298/72 Heading C2C [Also in Division C3] Cephalosporin compounds of Formula (I): wherein R is an optionally substituted, sixmembered carbocyclic or five-membered heterocyclic radical; and R<SP>1</SP> is hydrogen or an organic radical containing at least one S, O or N atom linked to the 3-methylene carbon atom, are prepared by N-acylating a 7-aminocephem compound of Formula (III) with an α-substituted-α-amino acid of formula: R-CH(NH 2 )COOH or an N-acylating derivative thereof, by means of an acylating enzyme from a microorganism which is capable of effecting the said reaction, and belongs to the genus: Mycoplana, Acetobacter, Protoaminobacter, Xanthomonas, Pseudomonas, Aeromonas, Escherichia, Staphylococcus, Arthrobacter, Proteus, Corynebacterium, Flavobacterium, Clostridium, Spirillum or Bacillus. The following compounds of Formula (I) are said to be novel: 7-(α-amino-1<SP>1</SP>-cyclohexenylacetamido)-3-desacetoxy-cephalosporanic acid, 7 - (α - amino - 1<SP>1</SP> - cyclohexenylacetamido)- cephalosporanic acid and 7-(α-amino-1<SP>1</SP>-cyclohexenylacetamido) - 3 - methoxymethyl - 3 - cephem-4-carboxylic acid. |
