| 摘要 |
8α-Ergolins (I; X = H, C1, Br, R1 = Me, Et, R2 = CH2-CN, NR3R4, R3 = H, C1-4 alkyl, R4 = formyl, C2-5 alkanoyl, or SO2R5, R5 = C1-4 alkyl, phenyl, pyridil, or NR6R7 = R6, R7 = H or C1-4 alkyl, R6 = R7 = (CH2)n or (CH2)2 -A(CH2)2, n = 3-7, A = C1-4 alkyl or phenyl substituted oxygen, sulfur, nitrogen), useful as muscle relaxants or sedatives, were prepd. by manufg. 8αcyanomethylergolin through substitution of Z (exchangeable group in nucleophilic reaction) of II with cyan group and 8-aminoergolin by acylating III with acid reacting deriv.
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