| 摘要 |
Compounds of the general formula <IMAGE> or the DELTA <4> or DELTA <5(6)> derivatives thereof are obtained by reacting corresponding 11ss,18; 18,20-bisepoxypregn-20-enes with a heavy metal acylate which effects acyloxylation. If desired, functional groups in the resulting compounds are unblocked, in particular the 21-hydroxy group from the 21-acyloxy group. The meanings in the formulae are: R1 = free, esterified or etherified hydroxyl group together with H or free or ketalised oxo group R2 = acylated hydroxyl group. If no double bond is present in positions 4,5 or 5,6, that is to say in saturated compounds, the 5H atom can be in the alpha or ss position. The process can be used in particular for the preparation of aldosterone and its derivatives.
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