| 摘要 |
<p>The principal object of the invention is to provide a method for directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors or derivatives thereof which comprises subjecting such molecule to allylic oxidation utilizing selenium dioxide as the oxidizing agent. It is recognized that 1(Alpha)-hydroxylation is essential to impart biological activity to vitamin D compounds and their derivatives and the present invention provides an efficient and direct method for accomplishing the desired 1(Alpha)-hydroxylation. </p> |
