| 摘要 |
An excipient for use in manufacture of tablets, capsules, powders, microgranules and granules which consists essentially of a microcrystalline cellulose having an average degree of polymerization of 60 to 375 and obtained through acid hydrolysis or alkaline oxidative degradation of a celulosic substance selected from linters, pulps and regenerated fibers, said microcrystalline cellulose being a white cellulosic powder having an apparent specific volume of 1.6 to 3.1 cc/g, a repose angle of 35 DEG to 42 DEG , a 200-mesh sieve residue of 2 to 80% by weight and a tapping apparent specific volume of at least 1.4 cc/g and a pharmaceutical composition comprising a pharmaceutically active ingredient and the excipient. This excipient has improved flowability and moldability or compressibility whereby excellent pharmaceutical preparations may be easily provided. In addition, pharmaceutical compositions obtained using such excipient are excellent in various pharmaceutical characteristics such as rate of disintegration, rate of dissolution, etc. |
