| 摘要 |
PURPOSE:To prepare purine arabinoside useful as an antiviral agent, carcinostatic agent, etc., by reacting purine or its derivative with cytosine arabinoside in the presence of specific microorganisms. CONSTITUTION:Purine arabinoside is prepared by reacting purine, or 2-, 6-, or 8- substituted purine (e.g. xanthine) with cytosine arabinoside or cytosine arabinotide in an aqueous medium in the presence of cells of prin arabinoside-producing microorganism, at 10-70 deg.C and pH4-10. The purine arabinoside-producing microorganism is, e.g. Pseudomonas, Flavobacterium, Achromobacter, Salmonella, Citrobacter, Escherichia, Enterobacter, Aeromonas, Serratia, Erwinia, Proteus, Xanthomonas, Bacterium, etc., e.g. Enterobacter aerogenes ATCC 9621. |
