| 摘要 |
Basic substituted alkyl theophylline derivatives of the formula <IMAGE> (I) in which Alk is a straight or branched chain alkylene group with 2 to 4 carbon atoms and R is hydrogen or a methyl group are produced by catalytic hydrogenation of compounds of the formula <IMAGE> (II) where the phenolic hydroxyl groups and/or the secondary basic nitrogen atom can contain protective groups using as the solvent a compound of the formula <IMAGE> (III) where R', R'' and R''' are the same or different and are alkyl groups of 1 to 2 carbon atoms and R' together with R''' can also be an alkylene bridge with 3 to 4 carbon atoms and in a given case the protective groups present are split off. |
