NEW DAUNORUBICIN DERIVATIVES,THEIR PREPARATION,COMPOSITIONS CONTAINING THEM AND THEIR USE

摘要

Daunorubicin derivs. of formula (I) and their acid addition salts are new: (R = H or 1-2C alkyl). They are made by reacting 14-bromodaunorubicin (II) with a quat. ammonium phosphate. (I) are low toxicity antitumour agents particularly for treating lymphoblastic and myeloblastic actue leukaemia and solid tumours. The daily adult dose is 1-5 mg/kg intravenously. -