PRODUCTION OF (1,1-DITHIEN-(3)-YL-1-HYDROXY-(3)-PROPYL)-(1- PHENYL-1-HYDROXY-(2)-PROPYL)-AMINE AND (1,1-DITHIEN-(3)-YL- (1)-PROPEN-(3)-YL)-(1-PHENYL-(2)-PROPYL)-AMINE

摘要

[1,1-dithien-(3)-yl-1-hydroxy-(3)-propyl]-[1-phenyl-1-hydroxy-(2)-prop yl]-amine is prepared by condensing thien-(3)-yl lithium with a beta -halogen propionic acid alkyl ester of the formula (II) where R is a lower alkyl group and Hal is chlorine, bromine or iodine, in an inert medium at a temperature below -50 DEG C. to form a compound of the formula (III) which is then reacted with 2-amino-1-hydroxy-1-phenylpropane in an inert medium in the presence of a basic compound. The product cn be converted to [1,1-dithien-(3)-yl-(1)-propen-(3)-yl]-[1-phenyl-(2)-propyl]-amine by dehydration.