Antiulcer heterocyclyl-alkylthio-alkyl-guanidine derivs. prepn. - by reacting a heterocyclyl-alkyl mercaptan with e.g. an aziridine-carboxamidine (nl 2.7.79)

摘要

Prodn. of guanidine derivs. of formula (I) comprises reacting a mercaptan deriv. of formula Het-(CH2)m-SM (III) is reacted with a guanidine of formula (IV). In the formulae, Het is opt. substd. 5- or 6-membered heterocyclic residue with 1 or 2 N-atoms; m is 1,2,3 or 4; R1 is H or 1-4C alkyl; R2 is CN or NO2; M is H or alkali metal; and Y is 2-oxo-3-oxazolidinyl, ethyleneimino or 2-haloethylamino. The intermediates 4-methyl-5-mercaptomethyl-imidazole and 1-(N-methyl-N'-cyano-carboxamido) -azinidine are also new. (I) are histamine H2 receptor blockers useful against gastric ulcers.