发明名称 |
Vigilance increasing and psycho-stimulant 10-bromo-vincamine - prepd. e.g. by redn. and rearrangement of 15-bromo-1,2-di:dehydro-3-hydroxy-aspidospermidine-3-carboxylic acid methyl ester |
摘要 |
<p>New vincamine derivs. is 10-bromo-vincamine (I) in optically active or racemic form. (I) and its physiologically tolerable acid addn. salts have vigilance-increasing and psychostimulant activity. Prepn. is by rearrangement of a cpd. (II) (where n is 0 and X is oxygen; or n is 1, X is H and Y is an anion. When n is 0, the rearrangement is carried out in the presence of a reducing agent (pref. triphenylphosphine). The rearrangement can be affected under acidic conditions, 10-epibromovincamine formed as by-product can be converted into (I) by e.g. boiling in xylene with silver or mercury (I) acetate.</p> |
申请公布号 |
DE2800063(A1) |
申请公布日期 |
1979.07.12 |
申请号 |
DE19782800063 |
申请日期 |
1978.01.02 |
申请人 |
SANDOZ-PATENT-GMBH |
发明人 |
PFAEFFLI,PAUL,DR.;WALDVOGEL,ERWIN |
分类号 |
C07D461/00;C07D471/20;(IPC1-7):C07D471/16;A61K31/445 |
主分类号 |
C07D461/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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