| 摘要 |
Novel thiophene-acetic acid derivatives of the formulae <IMAGE> I and <IMAGE> II wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R1 is selected from the group consisting of lower alkyl of 1 to 4 carbon atoms and hydrogen and R2 is selected from the group consisting of hydrogen, lower alkyl of 1 to 7 carbon atoms and optionally substituted with at least one hydroxy group or an oxygen atoms-containing heterocycle,di-lower alkylamino-lower alkyl, N-heterocyclic alkyl, alkali metals, alkaline earth metals, aluminum and -H,NH (lower alkyl)2 and Ar is selected from the group consisting of phenyl, optionally substituted with at least one member of the group consisting of halogen, trihalogenomethyl, lower alkyl, lower alkoxy and carboxyl, cyclohexyl, thienyl, furyl, tetrahydrofuryl and pyridyl, and in formula II, ArCO is attached to one of the positions alpha to the sulfur atom, which compounds have analgesic and anti-inflammatory activity and their preparations.
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