| 摘要 |
<p>This invention relates to rifamycin derivative of the formula: wherein Me represents a methyl group, n represents 3 or 4, g represents 0, 1 or 2; each R represents a lower alkyl group selected from methyl or ethyl substituting a hydrogen atom of a group -CH2-. These compounds are prepared by reacting 3-formylrifamycin SV with an aminopiperazine of the formula: wherein n, g and R are as defined above. The novel rifamycin derivatives of the invention are useful because they possess the usual broad spectrum activity perculiar to refamycin derivatives coupled with extremely high activity and low toxicity permitting control of bacertial infections by oral administration with long intervals between doses, for example, it has been found that a single weekly dose will give effective control.</p> |
