| 摘要 |
<p>Benzothiadiazine derivs. of formula (I) and their salts are new (where R and R1 are H, halogen, CF3, alkyl, alkoxy, alkoxyalkyl, alkylthio, alkanoyl, ArCO, ArSO2, ArSO, ArO, ArS or Ar'CO; Ar is phenyl opt. substd. by alkyl, alkoxy, halogen, NO2 or NH2; Ar' is thienyl or pyridyl opt. substd. by alkyl; R2 and R3 are H or alkyl; R4 is NH2, NHR5 or NR5R6, where R5 and R6 are alkyl, phenyl or phenylalkyl, or R5 can be linked to A to form a 5- or 6-membeted heterocyclic ring, or R5+R6 can form an opt. substd. 6- to 10-membered azabicycloalkyl gp.; or R4 is a 5- to 7-membered cycloalkyleneimino gp. which is opt. interrupted by O, S, NH or NR5 and/or substd. by 1 or 2 alkyl gps. and/or contains 1-3 double bonds in the rings; A is alkylene opt. substd. by alkyl and/or by OH, acyloxy or alkoxy). Cpds. (I) have favourable effect on circulation, no effect on carbohydrate metabolism and no diuretic activity.</p> |
