| 摘要 |
19-Oxygenated steroid compounds of the pregnane series of the formula I <IMAGE> (I) in which R1 represents a hydrogen atom, and R2 represents an alpha -oriented lower alkanoylthio group, or R1 and R2 together represent a carbon-carbon bond or an alpha -or beta -oriented methylene radical, R3 represents a free hydroxymethyl group or a hydroxymethyl group etherified by a lower alkyl or esterified by a lower alkanoyl; or represents a formyl group, a carboxyl group or a lower alkoxycarbonyl group, and R4 represents a hydrogen atom or the acyl radical Ac of a carboxylic acid, and corresponding 1,2-dehydro derivatives have valuable aldosterone-antagonizing properties with a minimum effect on sexual functions. As the compounds reduce the excessive sodium retention and potassium excretion induced by aldosterone, they are especially useful as the active ingredient in pharmaceutical preparations for alleviating diseases involving hyperaldosteronismus in man and other warm-blooded animals. |
