| 摘要 |
<p>A class of novel .beta.-amino penicillins of formula (IV) useful as antibacterial agents: (IV) and non-toxic salts and hydrolysable esters thereof, in which formula R is a C1 to C6 straight or branched chain alkyl group, a C5 to C7 cycloalkyl or cycloalkenyl group; R1 is hydrogen or a C1 to C6 alkyl group; or R and R1 taken together represent a C5 to C6 alkylene group which may be interrupted by a hetero atom. According to the process of preparation 6-aminopenicillanic acid or a salt or ester thereof or the reaction product of 6-aminopenicillanic acid with an organo silicon compound is treated with a reactive acylating derivative of an acid of the general formula (V) (V) wherein R and R1 are as defined in claim 1 and X is a nitrogen containing group which may be converted into a primary amino group, and subsequently converting the group X into a primary amino group.</p> |
