| 摘要 |
Quinazolinone derivatives of the formula, WHEREIN R is a polyalicyclic hydrocarbon group; R1 and R2 are independently a hydrogen atom, a nitro group, a trifluoromethyl group or a methylsulfonyl group; R3 is a phenyl group, a substituted phenyl group, a pyridyl group or a thienyl group; and n is 0 or an integer of 1 to 3, have potent antiviral activity with low toxicities. These compounds can be prepared using a variety of processes analogous to known methods, for example, by oxidizing a 3,4-dihydro-2(1H)-quinazolinone having a polyalicyclic hydrocarbon group bonded through an alkylene group at the 1 position. |
