摘要 |
An 8-azaprostaglandin of formula: <IMAGE> is prepared by saponifying, in an alcohol medium and using an alkali metal hydroxide, an ester of general formula: <IMAGE> in which R represents a linear or branched alkyl containing 1 to 7 carbon atoms, and then the alkali metal salt thus formed is hydrolysed using a strong acid. The derivative thus prepared in a completely synthetic way can exist in the form of optical isomers, positional isomers or a mixture of these isomers. However, its chemical structure is simpler than that of PGE1 because the asymmetry of the 8 and 11 carbons is suppressed. The derivative of the invention has the properties of PGE1, in particular a more specific bronchodilatory activity than that of PGE1. It can be used especially in the treatment of asthma.
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