| 摘要 |
Cyproheptadine derivatives of formula:
<CHEM>
or pharmaceutically acceptable salt thereof, wherein:
R represents (1) lower alkyl of 1-3 carbons, especially -CH3,
<CHEM>
-CH2CH2OH; and
R<1> represents hydrogen, lower alkyl of 1-3 carbon atoms, or fluoro,
are antipsychotic agents, with a low propensity to induce extrapyramidal side effects that are experienced with most major tranquilizers.
<??>Compounds (1) are generally prepared by treatment of the intermediate 5-carbinol with a dehydrating reagent, or by alkylation of the piperidine nitrogen with the appropriate alkyl or substituted alkyl group.
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