6-ACRYLAMIDOPENICILLINS AND 7-ACRYLAMIDOCEPHALOSPORINS

摘要

Novel antibiotic compounds which are 7.beta.-acrylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof wherein the acrylamido group has the structure wherein A is aryl group and B is a substituted or unsubstituted lower alkyl, lower alkenyl or lower alkynyl group; or an aryl, cycloalkyl or cycloalkenyl group. These compounds possess antibacterial activity against gram-positive and gram-negative organisms coupled with stability to .beta.-lactamases. The invention further relates to the administration of the compounds.