| 摘要 |
Title compds. [II; R = H, OH, -o-COR1 (R1 = C1-6 alkyl), Y = H or halogen , useful as antibiotics, were prepd. by dehydrohalogenation of lla-halo-6-demethyl-6-deoxy-6 -methylenetetracycline (I ; X = halogen) or its salts. Thus, I was dehydrohalogenated by PPh3, arsine or stibine in a solvent such as mono- or polyhydroxyalc., methoxyEtoH, ethoxyEtoH having 1-4 carbon atoms and dioxane, tetrahydrofuran, acetonitryl, DMF or acetone at 20-80≦̸C for 30-60 min to give I.
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