| 摘要 |
<p>Novel amidine compounds selected from the group consisting of bis-pyrrolinyl derivatives of phenothiazines, phenoxazines and acridans are obtained by reacting a phenothiazine, phenoxazine or acridan with a pyrrolidinone in the presence of phosphorus oxychloride. The phenothiazine, phenoxazine, or acridan can also be alkylated with 2-chloro-1-(1-pyrrolin-2-yl)-2-pyrroline to provide compounds of the invention. Typical examples of bis-pyrrolinyl derivatives are 2-methoxy-10-¢5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl!-phenothiazine, 10-¢1-pyrrolin-2-yl)-2-yl)-2-pyrrolin-2-yl!phenoxazine, and 9,9-dimethyl-10-¢5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl!acridan. The amidine compounds are useful as diuretics, smooth muscle relaxants and antithrombogenic agents.</p> |
