| 摘要 |
TITLE: OSMOTICALLY DRIVEN ACTIVE AGENT DISPENSER AND PROCESS FOR MAKING SAME An osmotically driven dispenser for releasing active agents, such as drugs, to liquid-containing environments, such as various body sites. The dispenser comprises a housing made from a semipermeable material, a flexible partition that divides the housing interior into two compartments, an initially nonflowable, osmotically effective active agent composition filling one of the compartments, an osmotically effective composition filling the other compartment, and an outlet passageway extending through the housing to the active agent-containing compartment. In operation liquid is imbibed from the environment through the housing into both compartments, thereby converting the active agent composition to a flowable form and causing the flexible partition to displace into the active agent-containing compartment and force active agent therefrom via the outlet passageway. The release rate of active agent from the dispenser is a function of the combined rate of liquid influx into both compartments. |
