| 摘要 |
A New antibacterially active 2,4-diamino-5-benzylpyrimidines of the formula <IMAGE> wherein R<1> denotes hydrogen or C1-6-alkyl; R<2> denotes hydrogen; R<3> denotes mercapto, C1-6-alkylthio, carboxy-C1-6-alkylthio, C1-6-alkoxy- C1-6-alkylthio, dimethylcarbamoylthio, -S(O)R' or -SO2R' and R<4> denotes C1-6-alkylthio, --S(O)R' or -SO2R', or R<1> denotes hydrogen; R<2> and R<4> denote C1-6-alkylthio, -S(O)R' or -SO2R', and R<3> denotes C1-6-alkoxy, mercapto, C1-6-alkylthio, carboxy- C1-6-alkylthio, dimethylcarbamoylthio, -S(O)R', -SO2R' or -NR''R''', or R<1> denotes hydrogen; R<2> denotes C1-6-alkoxy; R<3> denotes mercapto, C1-6-alkylthio, carboxy- C1-6-alkylthio, C1-6-alkoxy C1-6-alkylthio, dimethylcarbamoylthio, -S(O)R' or -SO2R', and R<4> denotes C1-6-alkylthio, -S(O)R' or -SO2R', or R<1> denotes hydrogen; R<2> denotes halogen; R<3> denotes C1-6-alkylthio, -S(O)R' or -SO2R', and R<4> denotes C1-6-alkylthio, -S(O)R' or SO2R', or R<1> denotes hydrogen; R<2> denotes halogen or C1-6-alkoxy; R<3> denotes mercapto, C1-6-alkylthio, carboxy- C1-6-alkylthio, carbalkoxy-C1-6- alkylthio, cyano- C1-6-alkylthio, C1-6-alkoxy-C1-6-alkylthio, C1-6-alkoxy-C1-6- alkoxy-C1-6-alkylthio, dimethylcarbamoylthio, -S(O)R' or SO2R', and R<4> denotes halogen or C1-6-alkoxy; R' denotes C1-6-alkyl; R'' and R''' independently of one another denote hydrogen or C1-6-alkyl or together denote C2-6-alkylene (possibly with 1-3 double bonds), and their physiologically compatible salts, a process for their preparation, as well as pharmaceutical preparations based on these compounds and the production of said pharmaceutical preparations. B Aldehydes of general formula <IMAGE> with the exception of 3,4-bis(methylthio)-benzaldehyde. |
