| 摘要 |
Disclosed are novel 6-oxygenated-3,20-dioxo-pregnane derivatives of the general formula I
<CHEM>
and specified 1,2-dihydroderivatives thereof.
<CHEM>
wherein Z represents specified acylgroups.
<??>The other substituents of formula I include those commonly met in known corticosteroids.
<??>The novel compounds may be prepared by methods known per se. The 6-acyloxy compounds of formula I are preferably prepared by subjecting a corresponding 6-oxo-compound of formula II, as herein defined, to esterification conditions. The 6-oxo-compounds of formula I are preferably prepared by oxidation of the corresponding 6-hydroxy-6,7-dihydro compounds. The novel compounds exhibit anti-inflammatory activity and are therefore useful in the treatment and control of inflammatory conditions.
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