PROCESS FOR THE PRODUCTION OF 1-AMINO-3-PHENYL INDOLES DERIVATIVES HAVING ANTIMICROBIAL AND ANTIDEPRESSANT PROPERTIES

摘要

A process is disclosed for the preparation of novel 1-amino-3-phenylindole derivatives having pharmacological activity, the compounds having the general formula wherein R1 is hydrogen, C1-C3 alkyl or C1-C3 dialkylaminoC2-C5 alkyl: R2 is C1-C3 dialkylamino-C2-C5 alkyl, C2-C4 alkanoyl, C1-C3 dialkylamino-C2-C4 alkanoyl, aroyl or nicotinoyl; R3 is hydrogen, C1-C3 alkyl or halogen; and R4 is hydrogen, C1-C3 alkyl, C1-C3 alkoxy or halogen; the process requiring coupling of 1-secondary amino-3-phenylindoles with the appropriate alkyl, alkanoyl, aroyl or nicotinoyl halide or precursor therof wherby a product is obtained into which an appropriate dialkylamino group may be introduced.