| 摘要 |
N-(mercaptoacyl) amino acids having mol. formula RCH(SH)CONHCHR' (CH2)n Co2H(1) (R=ph, C6H4 -CIP, Me, H, R1=H, Me, PhCH2, Me2CHCH2, Ph, n=0,1,4) were prepd. Thus, RCHXCOX(11) (X, X1=halogen group) condensated with NH2CHR1 (CH2)nCO2H(III) gave RCHXCONHCHR1 (CH2)n CO2H(IV) in water or org. solvent contg. NaOH. TV was treated with thiobenzoic acid to give RCHMCONHCHR1 (CH2)nCO2 H(V) (M=S-contg. radical), and then V was hydrolyzed to give I. I exhibited various pharmacological activity against metabolic diseases.
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