| 摘要 |
<p>1292197 Disruption of viruses AMERICAN HOME PRODUCTS CORP 12 May 1970 [16 May 1969] 22757/70 Heading A5B Viruses are disrupted by a method including the steps of bringing the intact virus, in an aqueous medium such as an allantoic fluid, into contact with a wetting agent and a trialkyl phosphate, preferably tri-(n-butyl) phosphate, having a solubility in water of not substantially more than 1% by weight at 25‹C. and separating the aqueous medium and disrupted virus from the trialkyl phosphate. The wetting agent may be non-ionic, e.g. a polyoxyethylene sorbitan higher fatty acid partial ester such as a polyoxyethylene sorbitan monolaurate or mono-oleate. The disrupted viruses are used to prepare diagnostic and immunogenic vaccines. Influenza, rabies, Newcastle disease, mumps, mice pheumonia, easter equine encephalomyelitis, Saint Louis encephalitis, Japanese encephalitis, yellow fever, dengue, West Nile, Theile GD VII, encephalomyocarditis, lymhocytic chorimeningitidis and vesicular stomatitis viruses are referred to.</p> |
| 申请人 |
AMERICAN HOME PRODUCTS CORP., NEW YORK, N.Y. (V.ST.A.) |
发明人 |
NEURATH, ALEXANDER ROBERT, PHILADELPHIA, PA. (V.ST.A.) |
