| 摘要 |
Chando-desethyl-apovincamine derivs. of formula (I) and their addn.salts, as the racemate or optical isomers, are new. In the formula R is H, 1-5C opt. branched, opt. unsatd. alkyl or benzyl and Z is H, alkyl, hydroxy, acyloxy, carbamoyloxy, methoxy or halo. Cpds. where Z is H and R is methyl and ethyl are specifically claimed.- Used for the treatment of cardio-circulatory and cerebro-vascular troubles and intermediates (I) have antianoxic and psychotropic activity and are used to treat vigilance troubles behavioural problems due to cerebral vascular damagE, cerebral sclerosis, geriatric states and as sedatives for treatment of lapses due to cranial traumatism and depression. They are administered orally, rectally or parenterally in unit doses of 0.5-700 mg. Usual daily doses are 1-500 mg
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