Antithrombotic compositions containing benzisothiazolones.

摘要

This invention relates to a pharmaceutical composition useful in the treatment of arterial thrombosis. A combination of a non-steroidal anti-inflammatory agent with a benzisothiazolone of formula (I) is found to be capable of inhibiting the aggregation of blood platelets to a greater degree than each of the components separately. <CHEM> R<1> and R<2> represent a variety of substituent groups; X represents a bond or an alkylene chain; and R represents a heterocyclic group. When the anti-inflammatory agent contains a carboxylic acid group, the combination with compound (I) may be in the form of a salt.