发明名称 |
Hydrosoluble rifamycins and process for their preparation |
摘要 |
This application relates to hydrosoluble rifamycins consisting of a molecular associations between a rifamycin derivative and an alkaline salt of an organic acid in a molar ratio 1 rifamycin to 0.5 to 5 alkali metal salt. These hydrosoluble rifamycins are obtained by solubilization of the respective rifamycin derivatives with the selected solubilizing agent, in a suitable organic solvent and they are isolated through dilution with a hydrocarbon, after a vacuum concentration by filtration and drying, or through evaporation. These products realize a prolonged gutliver recycling and a lower toxicity, against the liver cell.
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申请公布号 |
US4150023(A) |
申请公布日期 |
1979.04.17 |
申请号 |
US19770812428 |
申请日期 |
1977.07.01 |
申请人 |
INTREPRINDEREA DE ANTIBIOTICE IASI |
发明人 |
NITELEA, ION;SAUCIUC, ALEXANDRU;PAUNESCU, EUGENIU;ALBU, MARGARETA;DIACONESCU, CONSTANTIN |
分类号 |
C07D498/08;(IPC1-7):C07D498/08 |
主分类号 |
C07D498/08 |
代理机构 |
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代理人 |
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地址 |
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