发明名称 Process for the preparation of 1,4-benzodioxins
摘要 Compounds of formula (I) <IMAGE> in which: - n is an integer equal to 2 or 3; and - R1 and R2 each denote a C1 to C4 alkyl radical or form, jointly with the nitrogen atom to which they are bonded, a pyrrolidino, piperidino or hexamethyleneimino radical, are prepared, as well as their pharmacologically acceptable salts. A corresponding acetyl-5-hydroxy-1,4-benzodioxin is condensed with a chloroalkylamine in acetone medium and in the presence of potassium carbonate. These new compounds can be used for the preparation of medicaments for the treatment of circulatory insufficiency and of asthma and have the following pharmacological activities: vasodilatory, antibronchial- constricting, hypotensive and spasmolytic properties.
申请公布号 CH610322(A5) 申请公布日期 1979.04.12
申请号 CH19750015225 申请日期 1975.11.24
申请人 DELALANDE SA 发明人 CLAUDE FAURAN;GUY BOURGERY;GUY RAYNAUD;YVES BAILLY
分类号 A61K31/357;C07D319/18;(IPC1-7):C07D319/18;C07D405/12 主分类号 A61K31/357
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