发明名称 |
Intermediates for polycyclic quinonoid antibiotics |
摘要 |
There is provided a novel method of synthesizing certain tetracyclic quinones. In particular, there is provided a novel route to the synthesis of (+)-7-deoxydaunomycinone and analogs thereof, which includes the provision of novel tri- and tetracyclic quinone intermediates. The -7-deoxydaunomycinone derived from naturally occurring daunomycin is a known compound, which is itself an intermediate in the preparation of the clinically accepted anti-tumor antibiotics daunomycine and its derivative adriamycin.
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申请公布号 |
US4147706(A) |
申请公布日期 |
1979.04.03 |
申请号 |
US19780868373 |
申请日期 |
1978.01.10 |
申请人 |
RESEARCH CORPORATION |
发明人 |
KENDE, ANDREW S.;MILLS, JOHN E.;TSAY, YUH-GENG |
分类号 |
C07C69/013;A61K31/12;A61K31/215;A61K31/22;A61P35/00;C07C45/00;C07C46/00;C07C46/02;C07C46/06;C07C50/26;C07C50/36;C07C50/38;C07C67/00;C07C69/017;(IPC1-7):C07C87/10 |
主分类号 |
C07C69/013 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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