| 摘要 |
Nitroxyalkylamine derivative of the general formula: (I) wherein R1 is a hydrogen atom, a straight-chained or branched, saturated or unsaturated C1-C8-alkyl radical, a C3-C8-cycloalkyl or C3-C8-cycloalkenyl radical, an aminocarbonyl, C1-C6-alkylaminocarbonyl or di-C1-C6-alkylaminocarbonyl radical, R2 is a hydrogen atom, a straight-chained or branched, saturated or unsaturated C1-C6-alkyl radical or a C3-C8-cycloalkyl or cycloalkenyl radical or R2, together with R1 and the nitrogen atom to which they are attached, form a heteroaliphatic ring containing up to 6 carbon atoms in which one or two carbon atoms can be replaced by nitrogen or oxygen atoms, A is a valency bond or a straight-chained or branched alkylene radical containing up to 8 carbon atoms, in which a -CH2- group can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms, B is a straight-chained or branched alkylene radical containing up to 8 carbon atoms, in which a -CH2-group can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms and X is an -NR3-CO-or -CO-NR3- radical, in which R3 is a hydrogen atom or a saturated or unsaturated alkyl radical containing up to 6 carbon atoms or, when X is an -NR3-CO- radical, R3, together with the nitrogen atom and a carbon atom of the group A, bridge a heterocyclic ring containing 4 to 6 carbon atoms or R3, together with R2, A and the two nitrogen atoms, bridge a heterocyclic ring containing 3 to 5 carbon atoms; and the opticallyactive forms and physiologically compatible, pharmaceutically acceptable salts thereof, may be used in the prophylaxis or treatment of heart and circulatory diseases, for example, angina pectoris.
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