Surface active sequenced oligomer - for use in cosmetic and pharmaceutical compsns.

摘要

New surface-active sequenced oligomer is of formula P-O-(C2H3(CH2B)O)-n-(C2H3(CH2A)O)-m-(C2H3(CH2B)O)-nQ (I) in (I) -C2H3(CH2B)O- represents the 2 isomers -CH2-CH (CH2B)-O- and -CH(CH2B)-CH2-O-, and -C2H3(CH2A)O- represents the 2 isomers -CH2-CH(CH2A)-O- and -CH (CH2A)-CH2-O-; either P or Q is H, the other being 1-20C alkyl; A is R-CH2- or R'-O-(where R is linear 4-16C alkyl, and R' is 4-20C alkyl); B is -OH, -NR1R2, -R1R2N- O, R1R2N-encircled positive OH V encircled negative, R1R2N encircled positive H V encircled negative, R1R2R3N encircled positive Z encircled negative, R4S - (O)a (where R1 and R2 are 1-3C (hydroxy)alkyl or form with the adjacent N a 6-membered heterocyclic ring, pref. a piperidino or morpholino ring; R3 is methyl or ethyl; R4 is 1-3C (hydroxy)alkyl or dihydroxyalkyl, pref. methyl, (hydroxy)ethyl, or dihydroxypropyl; Z encircled negative is pref. HSO3 encircled negative, CH3SO3 encircled negative, CH3SO4 encircled negative, CH3-C6H4-SO3 encircled negative; R1R2 encircled positive NH V encircled negative and R1R2N-encircled positive OH V encircled negative represent an amine salt or amine oxide pref. a chlorohydrate, bromohydrate, sulphate, phosphate, acetate, lactate, tartrate; a i 0 or 1); m is 2-10; n and n' are 2-25, and n or n' can be 0. (I) can be used in cosmetic or pharmaceutical compsns., e.g. hair conditioner. The oligomer has high surface activity, good water affinity, and produces very low irritation of the skin and mucous membrane partic. of the eyes.