发明名称 |
PROCESS FOR PREPARATION OF 3-HALOMETHYLCEPHENS |
摘要 |
3-Halomethyl-3-cephems are provided by reacting a 3-methylenecepham with an alkali metal salt of a lower alcohol or a bicyclic amidine base in the presence of a positive halogenating agent at a temperature ranging from -80 DEG to about 20 DEG C. The 3-halomethylcephems provided by this invention are useful intermediates for the preparation of known cephalosporin antibiotics. |
申请公布号 |
PH12481(A) |
申请公布日期 |
1979.03.23 |
申请号 |
PH19730000195 |
申请日期 |
1977.03.18 |
申请人 |
LILLY CO ELI |
发明人 |
KOPPEL G |
分类号 |
A61K31/545;A61K31/546;C07C;C07D;C07D501/00;C07D501/04;C07D501/16;C07D501/24;C07D501/28;C07D501/34;C07D501/57;C07D501/60 |
主分类号 |
A61K31/545 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|