CRYSTALLINE SESQUIHYDRATE OF 7-(D-AMINO-'-(P-HYDROXYPHENYL) ACETAMIDO)-3-(1,2,3,-TRIAZOL-5-YLTHIOMETHYL)- PHEM-4-CARBOXYLIC ACID

摘要

The specification discloses a novel cystalline sesquihydrate of 7-D-a-amino-a-(p-hydroxyphenyl)acetamido!-3- (1,2,3-triazol-5-ylthiomethyl)-3 cephem-4-carboxylic acid which is particularly useful as an antibacterial agent. The specification discloses a process for the preparation of this compound, which process comprises suspending 7-D-alpha-amino-alpha-(p-hydroxy-phenyl)aeetamido! -3-(1,2,3-triazol-5-ylthiomethyl-3-cephem-4-carboxylic acid methanol solvate in water at a pH range of approximately 2.5 - 7.0 and recovering the desired crystalline sesquihydrate product from the aqueous reaction mixture.