发明名称 |
THERAPEUTIC SYSTEM FOR ADMINISTERING CLONIDINE TRANSDERMALLY |
摘要 |
Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elicit alpha-adrenergic stimulation without intolerable side effects, followed by a substantially constant continuous dosage in the range of 0.1 to 100 mcg/hr that maintains said level. The system is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-clonidine reservoir lamina that is the source of the clonidine for the continuous constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-clonidine contact adhesive layer that is the source of the clonidine for the priming dose and the means by which the system is attached to the skin. |
申请公布号 |
AU2846277(A) |
申请公布日期 |
1979.03.08 |
申请号 |
AU19770028462 |
申请日期 |
1977.09.01 |
申请人 |
ALZA CORP. AND BOEHRINGER INGELHEIM G.M.B.H. |
发明人 |
SANTOSH KUMAR CHANDRASEKARAN;SIEGFRIED DARDA;ALAN S. MICHAELS;GARY W. CLEARY |
分类号 |
A61L15/00;A61K9/70;A61K31/415 |
主分类号 |
A61L15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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