D-HOMOSTEROIDS AND PROCESS FOR THE PREPARATION THEREOF

摘要

D-Homosteroids of the formula wherein R6 represents a hydrogen, fluorine or chlorine atom or a methyl group; R9 represents a hydrogen, fluorine, chlorine or bromine atom; R11 represents an oxo or (.alpha.-H,.beta.-OH) group when R9 represents a hydrogen atom or an oxo, (.alpha.-H,.beta.-OH), (.alpha.-H,.beta.-fluoro) or(.alpha.-H,.beta.-chloro) group when R9 represents a fluorine, chlorine or bromine atom with the proviso that, in the case of 9,11-dihalo compounds, the atomic number of the halogen atom in the 11-position is not less than the a-tomic number of the halogen atom in the 9-position; R17a represents a hydroxy or acyloxy group and R20 represents a hydrogen atom or a lower alkyl, halo-(lower alkyl), hydroxy-(lower alkyl), acyloxy-(lower alkyl), hydroxy-(lower alkoxycarbonyl)-.(lower alkyl) group and wherein the broken line in the 1,2-position denotes an optional carbon-carbon bond, which are useful for the manufacture of pharmaceutical preparations with endocrinal activity and methods for the preparation thereof.