| 摘要 |
Isopenicillins of the formula …<CHEM>… in which… R is acylamino, azido, or amino; and… M is hydrogen, a pharmaceutically acceptable cation, or a removable carboxylic acid protecting ester, can be prepared by ring-closing an appropriately 3-substituted-4- halomethyl beta -lactam of the formula …<CHEM>… in which… R min is acylamino or azido;… and when a compound (1) is required, in which R is amino, a protecting acyl group of an acylamino group R min is removed. Compound I show antibacterial activity against gram positive and gram negative organisms. |
