| 摘要 |
<p>Complete hepatitis A virus is extracted from the stools, blood or its derivs. are taken from subjects (man or animals) suffering from hepatitis A, or from the liver, bile, or any organ or fluid from an animal infected experimentally, by centrifuging, adsorption, chromatography or ultracentrifuging. The virus may then be conc. to the min. necessary for replication on diploid cultures. Replication is then effected by a series of passage on cell material of the virus, in the course of which the apparent speed of development of the virus accelerates, resulting in a large quantity, which is industrially exploitable, of hepatitis A virus, consisting of a mixt. of complete viral particles and empty capsides of genetic material. The complete viral particles are capable of producing a rapid and useful amount of viral material on diploid cells. Process is used to produce specific reactive antigens, immunoserums, and vaccines against hepatitis A.</p> |
