发明名称 |
Penetrating topical pharmaceutical compositions. |
摘要 |
A large group of lipophilic, pharmacologically active compounds can be effectively delivered across intact skin by applying them topically in a binary, penetration-enhancing vehicle containing (1) a C3-C4 diol, diol ester, or diol ether and (2) a cell envelopedisordering compound. This vehicle provides surprising enhancement of skin penetration for the pharmacological active, compared to either component alone.
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申请公布号 |
EP0043738(A2) |
申请公布日期 |
1982.01.13 |
申请号 |
EP19810303128 |
申请日期 |
1981.07.09 |
申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
WICKETT, RICHARD RANDALL;COOPER, EUGENE REX;LOOMANS, MAURICE EDWARD |
分类号 |
A61K9/00;A61K9/08;A61K31/19;A61K31/25;A61K31/405;A61K31/60;A61K47/00;A61K47/08;A61K47/10;A61K47/14;A61P17/00;A61P29/00;(IPC1-7):A61K9/06 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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