| 摘要 |
Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic acid derivatives having the formula <IMAGE> WHEREIN X is a sulfur or oxygen atom or the sulfinyl group, n is 1 or 2, m is 1 or 2, R1 is hydrogen, R2 is one of the radicals known in the chemistry of the penicillins, preferably 2-phenylacetyl, 2-amino-2-phenylacetyl, 5-methyl-3-phenyl-4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl, or R1 and R2 together represent a bivalent radical R3, preferably (hexahydro-1H-azepin-1-yl)methylene and their therapeutically acceptable non-toxic salts and process for preparing the same.
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