Process for the preparation of {107 ,{107 -dialkoxycarboxylic acid derivatives

摘要

omega , omega -Dialkoxycarboxylic acid derivatives I (amides and esters) are prepared by heating omega -alkoxylactams II with hydrogen halide in an alcohol. When using only a catalytical quantity of hydrogen halide, there are obtained the amides, when using a quantity of hydrogen halide which is at least about equimolar, there are obtained the esters of the corresponding omega , omega -dialkoxycarboxylic acids. Since the compounds I are acetals, they may be readily converted into the corresponding omega -formyl compounds. Both the acetals I and the corresponding omega -formyl compounds are valuable intermediates for the synthesis of for example prostaglandins, sexual attractants and antioxidants.