SUBSTITUERADE TRIFLUORMETYLBENSYLKARBAMIDER TILL ANVENDNING SOM MELLANPRODUKTER FOR FRAMSTELLNING AV KVEVE-SUBSTITUERADE TRIFLUORMETYLBENSYLAMINER OCH SETT ATT FRAMSTELLA KARBAMIDERNA

摘要

1475513 Oxazolines SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 20 June 1975 [20 June 1974] 27392/74 Heading C2C Novel compounds of Formula I in which X is a hydrogen or halogen atom or a trifluoromethyl radical, R 1 is a lower alkyl radical or a lower cycloalkyl radical, R 2 is a hydrogen atom or a lower alkyl radical, and R 3 and R 4 , which may be the same or different, are hydrogen atoms or lower alkyl radicals or together form an alkylene group having from 3 to 6 carbon atoms where "lower" denotes group containing up to 6 carbon atoms on salts thereof are prepared by cyclization of a compound of Formula II #-Haloethyl urens of Formula II above are prepared by reacting a compound of Formula III with a compound of formula Starting materials of Formula III are obtained by reduction of an oxime formed from an R 1 COPh(X)CF 3 ketone or by reaction of cyanogen bromide with the alcohol obtained by reduction of such a ketone. Pharmaceutical compositions in conventional forms for buccil, rectal, sublingual or parenteral administration and having anti-hypertensive activity comprises an above novel compound and a carrier or diluent.