| 摘要 |
PURPOSE:To prepare the titled compound useful as an intermediate of agricultural chemicals and pharmaceuticals, without using harmful raw material, in high yield, by reacting glyoxylic acid with benzene in essentially anhydrous state in the presence of a cation exchange resin, and hydrolyzing the reaction product. CONSTITUTION:Glyoxylic acid is made to react with benzen in an essentially anhydrous state in the presence of a cation exchange resin, at 50-80 deg.C, preferably using acetic acid as a cocatalyst. The objective compound can be prepared by hydrolyzing the resultant mandelic acid benzyl ester derivative. The cation exchange resin is preferably a strong acidic cation exchange resin of sulfonic acid type, e.g. Amberlite IR-120B, etc., and its amount is preferably about 50-300wt%, based on glyoxylic acid. The amount of acetic acid used as a cocatalyst is preferably 2-5mol per 1mol of glyoxylic acid. |
