PSYCHOPHARMACOLOGICALLY ACTIVE PEPTIDES AND PEPTIDE-DERIVA- TIVES

摘要

Biologically active novel peptides and peptide-derivatives of the general formula: I where A represents H-(L or D)Met, H-(L or D)Met(->O), H-(L or D)Met(->O2) desamino-Met, desamino-Met(->O), desamino-Met(->O2) or the group H2N-B-CO-; B represents a branched or straight-chain alkylene (C1-C6) or alkylidene (C1-C6) group; Q represents the amino-acid residue -NH-CHR-CO-; R represents alkyl (C1-C6), p-hydroxyphenylmethyl, 3-indolylmethyl or phenylmethyl; R1 and R2 represent hydrogen or an alkyl(1-6C) group, and Z represents N-(phenylalkyl)amino, N-( beta -indolylalkyl)amino, L-Trp-OH, L-Phe-OH, L-Trp-Gly-OH or L-Phe-Gly-OH, as well as the functional derivatives thereof.