发明名称 |
PROCESS FOR THE PURIFICATION OF PEPTIDES |
摘要 |
<p>PROCESS FOR THE PURIFICATION OF PEPTIDES Peptides of the calcitonin type when obtained by synthesis can be purified in a simple manner by forming inner salts, which precipitate from aqueous solutions of salts of the peptides with acids or bases when these solutions are adjusted to the isoelectric range. Impurities remain in solution, while the inner salts separate practically quantitatively. The precipitation is completed after several hours. The peptides can then be recuperated by treatment with an acid, especially a therapeutically suitable acid. The process affords products which are superior to those obtained by purification methods hitherto known and gives higher yields. Other long- chain peptides such as ACTH, insulin or glucagon cannot be purified in this manner.</p> |
申请公布号 |
CA1046053(A) |
申请公布日期 |
1979.01.09 |
申请号 |
CA19740215850 |
申请日期 |
1974.12.12 |
申请人 |
CIBA-GEIGY AG |
发明人 |
RITTEL, WERNER;BRUGGER, MAX;RINIKER, BERNHARD |
分类号 |
C07K1/14;A61K38/00;C07K1/113;C07K14/575;C07K14/585;(IPC1-7):07C102/00;07C103/52 |
主分类号 |
C07K1/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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