| 发明名称 |
Biotin intermediates |
| 摘要 |
A novel procedure for the preparation of biotin employing cysteine as the starting material is disclosed. This synthesis involves the formation of the thiophane ring by a 1,3-dipolar addition. By virtue of this process pure d-biotin can be obtained, thus obviating the need for chemical resolution. Novel intermediates are also disclosed.
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| 申请公布号 |
US4130713(A) |
申请公布日期 |
1978.12.19 |
| 申请号 |
US19770822119 |
申请日期 |
1977.08.05 |
| 申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
BAGGIOLINI, ENRICO G.;LEE, HSI L.;USKOKOVIC, MILAN R. |
| 分类号 |
C07C67/00;C07C313/00;C07C323/43;C07D333/36;C07D495/04;C07D498/04;(IPC1-7):C07D495/04 |
主分类号 |
C07C67/00 |
| 代理机构 |
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| 地址 |
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