发明名称 Process for preparation of alkali metal salts of ampicillin
摘要 A process for the preparation of an alkali metal salt of ampicillin, especially the sodium salt, which comprises adding to an aqueous suspension of ampicillin, at a temperature not exceeding about 4 DEG C, an aqueous solution of an equimolar or somewhat lesser amount of an alkali metal base, filtering the resulting solution until sterile, freezing the filtrate, and lyophilizing the frozen filtrate.
申请公布号 US4130558(A) 申请公布日期 1978.12.19
申请号 US19770797928 申请日期 1977.05.18
申请人 BOEHRINGER INGELHEIM GMBH 发明人 ROOS, OTTO;ESSIG, DIETER
分类号 C07D499/44;A61K9/14;A61K31/43;C07D;C07D499/16;C07D499/46;C07D499/68;(IPC1-7):C07D499/68 主分类号 C07D499/44
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